Bulgaria's economy, energy and tourism minister Traicho Traikov and health minister Stefan Konstantinov resigned on Thursday, the government said.
"Their resignations were reviewed by the executive committee of [the ruling party] GERB and were accepted both by the committee and by prime minister Boiko Borisov," the government's press office said in a statement.
The prime minister, in line with his obligations under the Constitution, will propose to parliament changes to the cabinet's lineup after nominating successors to the two outgoing ministers, the statement added.
No further details were immediately available.
In an interview for the Bulgarian National Television (BNT) on Friday morning, prime minister Boiko Borisov said that Bulgaria was running behind schedule with the big energy projects.
Traikov will be succeeded by his deputy Delyan Dobrev, Borisov said.
He said he has still not decided who will replace Konstantinov.
Konstantinov will leave the cabinet over the failed dialogue between the health ministry, the National Health Insurance Fund and the healthcare parliamentary committee, Borisov said.